2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-100822
    (R)-(+)-HA-966 123931-04-4 98.85%
    (R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
    (R)-(+)-HA-966
  • HY-100823
    (1S,3R)-ACPD 111900-32-4 98%
    (1S,3R)-ACPD is a mGluR agonist that can depolarize pyramidal cells.
    (1S,3R)-ACPD
  • HY-100837
    5-Iodowillardiine 140187-25-3 98%
    5-Iodowillardiine is a potent and selective kainate receptor agonist. 5-Iodowillardiine is selective for kainate receptors composed of hGluR5 subunits.
    5-Iodowillardiine
  • HY-100838
    cis-α-(Carboxycyclopropyl)glycine 117857-95-1 98%
    cis-α-(Carboxycyclopropyl)glycine (L-CCG III) is a potent, competitive glutamate uptake inhibitor. cis-α-(Carboxycyclopropyl)glycine is a substrate of glutamate transporters (GluT) (EC50: 13 μM, 2 μM for EAAT 1 and EAAT 2, respectively). cis-α-(Carboxycyclopropyl)glycine inhibits a Na+-dependent high-affinity L-glutamate uptake in glial plasmalemmal vesicles (GPV) and synaptosomes.
    cis-α-(Carboxycyclopropyl)glycine
  • HY-100842
    (R)-3C4HPG 13861-03-5 98%
    (R)-3C4HPG is an NMDA receptor antagonist.
    (R)-3C4HPG
  • HY-100843
    L-AP6 78944-89-5 98%
    L-AP6 is a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons.
    L-AP6
  • HY-100915
    SKF 97541 127729-35-5 98%
    SKF 97541 (CGP 35024) is a potent and selective GABAB agonist that can induce hyperpotential. SKF 97541 has antiepileptic activity.
    SKF 97541
  • HY-100916
    Arecaidine-propargyl ester tosylate 147202-94-6 98%
    Arecaidine-propargyl ester tosylate is a potent muscarinic receptor (mAChR) agonist.
    Arecaidine-propargyl ester tosylate
  • HY-100920
    Arcaine sulfate 14923-17-2 ≥98.0%
    Arcaine (sulfate) is a glutamate NMDA receptor inhibitor.
    Arcaine sulfate
  • HY-100922
    N-Acetylglycyl-D-glutamic acid 135701-69-8 98%
    N-Acetylglycyl-D-glutamic acid is a peptide with excitatory effect. N-Acetylglycyl-D-glutamic acid induces seizures in mice.
    N-Acetylglycyl-D-glutamic acid
  • HY-100924
    β-CCB 84454-35-3 98%
    β-CCB is a ligand for benzodiazepine receptor, which inhibits the binding of [3H]flunitrazepam and ethyl (3-[3H]carboline-3-carboxylate to benzodiazepine receptors, with Ki of 3-4 nM. β-CCB exhibits proconvulsant and anxiogenic effects.
    β-CCB
  • HY-100929
    GBR-12879 dihydrochloride 67469-45-8 98%
    GBR-12879 dihydrochloride is a potent inhibitor of dopamine uptake.
    GBR-12879 dihydrochloride
  • HY-100930
    L-693403 maleate 207455-21-8 98%
    L-693403 maleate is a high affinity and selective σ ligand. L-693403 maleate has the potential for physiological disease research.
    L-693403 maleate
  • HY-100939
    4-Chlorophenylguanidine hydrochloride 14279-91-5 99.07%
    4-Chlorophenylguanidine hydrochloride is an urokinase-type plasminogen activator inhibitor. 4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo.
    4-Chlorophenylguanidine hydrochloride
  • HY-100963
    U-54494A 112465-94-8 98%
    U-54494A is a benzamide derivative related to κ-opioid receptor agonists, U-54494A has an anticonvulsant activity.
    U-54494A
  • HY-100966
    BD-1008 dihydrobromide 138356-09-9 98.07%
    BD-1008 dihydrobromide is a selective sigma 1 (σ1) receptor antagonist with a Ki of 2 nM. BD-1008 dihydrobromide exhibits 4-fold selectivity over the sigma-2 receptor (Ki of 8 nM). BD-1008 dihydrobromide can be used for the study of neurological diseases.
    BD-1008 dihydrobromide
  • HY-100980
    HEAT hydrochloride 30007-39-7 98%
    HEAT (BE2254) hydrochloride is a selective alpha 1 adrenergic receptor antagonist. HEAT hydrochloride, a phenethylamine derivative, shows pKis of 9, 9.1, and 8.57 for alpha 1a, alpha 1b and alpha 1c, respectively.
    HEAT hydrochloride
  • HY-100981
    MR-16728 hydrochloride 207403-36-9 98%
    MR-16728 hydrochloride is a compound that promotes the release of acetylcholine and has activity that enhances the release of acetylcholine. MR-16728 hydrochloride inhibits acetylcholine release induced by KCl depolarization. MR-16728 hydrochloride also inhibits Ca(2+)-ATPase activity in pure presynaptic membranes. The half-maximal effect of MR-16728 hydrochloride occurs at a concentration of 13.5 μM. MR-16728 hydrochloride significantly enhances the release of acetylcholine in the presence of low concentrations of calcium (approximately 10 μM range). Enhanced acetylcholine release was also observed with MR-16728 hydrochloride in proteoliposomes loaded with mediator proteins.
    MR-16728 hydrochloride
  • HY-100998
    Metaphit 96316-00-6 98%
    Metaphit is a specific PCPantagonist and site-directed acylating agent of the [3H]phencyclidine binding site in rat brain homogenates. Metaphit prevents PCP-induced locomotor behavior through presynaptic mechanisms.
    Metaphit
  • HY-101009
    Methiothepin maleate 19728-88-2 98%
    Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
    Methiothepin maleate
Cat. No. Product Name / Synonyms Application Reactivity